Ontology highlight
ABSTRACT:
SUBMITTER: Krause JC
PROVIDER: S-EPMC3187471 | biostudies-literature | 2011 Oct
REPOSITORIES: biostudies-literature
Krause Jens C JC Tsibane Tshidi T Tumpey Terrence M TM Huffman Chelsey J CJ Basler Christopher F CF Crowe James E JE
Journal of virology 20110817 20
The conserved influenza virus hemagglutinin (HA) stem domain elicits cross-reactive antibodies, but epitopes in the globular head typically elicit strain-specific responses because of the hypervariability of this region. We isolated human monoclonal antibody 5J8, which neutralized a broad spectrum of 20th century H1N1 viruses and the 2009 pandemic H1N1 virus. Fine mapping of the interaction unexpectedly revealed a novel epitope between the receptor-binding pocket and the Ca₂ antigenic site on HA ...[more]