Ontology highlight
ABSTRACT:
SUBMITTER: Fernandez-Funez P
PROVIDER: S-EPMC3187883 | biostudies-literature | 2011 May
REPOSITORIES: biostudies-literature
Communicative & integrative biology 20110501 3
The Prion protein (PrP) is a membrane-tethered glycoprotein that plays a central role in a unique class of neurodegenerative diseases that affect humans and other mammals. Prion diseases have genetic and sporadic origins, but their infectious nature sets them apart from other neurodegenerative disorders. According to the "protein-only" hypothesis, misfolded PrP conformers (prions) are responsible for both spongiform degeneration of the brain and disease transmissibility. Thus, understanding PrP ...[more]