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Schizophrenia and genetics: new insights.

ABSTRACT: There is consistent evidence that the principal etiology of schizophrenia involves predisposing genetic factors. Recent years have seen several new insights in the genetics of schizophrenia. Several chromosomal regions show significant evidence that they contain schizophrenia susceptibility genes. A clinically relevant genetic subtype of schizophrenia (22q deletion syndrome) has been identified. There is new evidence that spontaneous mutations may play a role. There are new recommendations for genetic counseling. The progress to date suggests that understanding of a neurodevelopmental pathway from genetic susceptibility to schizophrenia will soon be fundamentally altered by molecular genetic advances in this complex disease.

SUBMITTER: Bassett AS

PROVIDER: S-EPMC3188303 | biostudies-literature | 2002 Aug

REPOSITORIES: biostudies-literature

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Schizophrenia and genetics: new insights.

Bassett Anne S AS Chow Eva W EW Weksberg Rosanna R Brzustowicz Linda L

Current psychiatry reports 20020801 4

There is consistent evidence that the principal etiology of schizophrenia involves predisposing genetic factors. Recent years have seen several new insights in the genetics of schizophrenia. Several chromosomal regions show significant evidence that they contain schizophrenia susceptibility genes. A clinically relevant genetic subtype of schizophrenia (22q deletion syndrome) has been identified. There is new evidence that spontaneous mutations may play a role. There are new recommendations for g ...[more]

PMID: 12126600

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