Ontology highlight
ABSTRACT:
SUBMITTER: Werner EJ
PROVIDER: S-EPMC3188311 | biostudies-literature | 2007 Feb
REPOSITORIES: biostudies-literature
Werner Eric J EJ Avedano Stefano S Botta Mauro M Hay Benjamin P BP Moore Evan G EG Aime Silvio S Raymond Kenneth N KN
Journal of the American Chemical Society 20070130 7
The design, synthesis, and relaxivity properties of highly soluble TACN-capped trishydroxypyridonate-Gd(III) complexes are presented. Molecular mechanics modeling was used to help design a complex capable of possessing three water molecules in the inner metal coordination sphere, an attractive property for high-relaxivity MRI contrast agents. The measured relaxivities of 13.1 and 12.5 mM-1 s-1 (20 MHz, 298 K) for two TACN-capped complexes are among the highest known relaxivities of low-molecular ...[more]