Ontology highlight
ABSTRACT:
SUBMITTER: Garimella PD
PROVIDER: S-EPMC3188312 | biostudies-literature | 2011 Sep
REPOSITORIES: biostudies-literature
Garimella Praveena D PD Datta Ankona A Romanini Dante W DW Raymond Kenneth N KN Francis Matthew B MB
Journal of the American Chemical Society 20110826 37
MRI contrast agents providing very high relaxivity values can be obtained through the attachment of multiple gadolinium(III) complexes to the interior surfaces of genome-free viral capsids. In previous studies, the contrast enhancement was predicted to depend on the rigidity of the linker attaching the MRI agents to the protein surface. To test this hypothesis, a new set of Gd-hydroxypyridonate based MRI agents was prepared and attached to genetically introduced cysteine residues through flexibl ...[more]