Ontology highlight
ABSTRACT:
SUBMITTER: Cupit PM
PROVIDER: S-EPMC3188324 | biostudies-literature | 2011 Oct
REPOSITORIES: biostudies-literature
International journal for parasitology 20110822 12
A vaccine against schistosomiasis would contribute significantly to reducing the 3-70 million disability-adjusted life years lost annually to the disease. Towards this end, inoculation with the large extracellular loop (EC-2) of Schistosoma mansoni tetraspanin-2 protein (Sm-TSP-2) has proved effective in reducing worm and egg burdens in S. mansoni-infected mice. The EC-2 loop of Schistosoma japonicum TSP-2, however, has been found to be highly polymorphic, perhaps diminishing the likelihood that ...[more]