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Polymorphism associated with the Schistosoma mansoni tetraspanin-2 gene.


ABSTRACT: A vaccine against schistosomiasis would contribute significantly to reducing the 3-70 million disability-adjusted life years lost annually to the disease. Towards this end, inoculation with the large extracellular loop (EC-2) of Schistosoma mansoni tetraspanin-2 protein (Sm-TSP-2) has proved effective in reducing worm and egg burdens in S. mansoni-infected mice. The EC-2 loop of Schistosoma japonicum TSP-2, however, has been found to be highly polymorphic, perhaps diminishing the likelihood that this antigen can be used for vaccination against this species. Here, we examine polymorphism of the EC-2 of Sm-TSP-2 in genetically unique worms derived from six individuals from Kisumu, Kenya.

SUBMITTER: Cupit PM 

PROVIDER: S-EPMC3188324 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature

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Polymorphism associated with the Schistosoma mansoni tetraspanin-2 gene.

Cupit Pauline M PM   Steinauer Michelle L ML   Tonnessen Bradley W BW   Eric Agola L L   Kinuthia Joseph M JM   Mwangi Ibrahim N IN   Mutuku Martin W MW   Mkoji Gerald M GM   Loker Eric S ES   Cunningham Charles C  

International journal for parasitology 20110822 12


A vaccine against schistosomiasis would contribute significantly to reducing the 3-70 million disability-adjusted life years lost annually to the disease. Towards this end, inoculation with the large extracellular loop (EC-2) of Schistosoma mansoni tetraspanin-2 protein (Sm-TSP-2) has proved effective in reducing worm and egg burdens in S. mansoni-infected mice. The EC-2 loop of Schistosoma japonicum TSP-2, however, has been found to be highly polymorphic, perhaps diminishing the likelihood that  ...[more]

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