Effects of green tea catechins on gramicidin channel function and inferred changes in bilayer properties.
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ABSTRACT:
SUBMITTER: Ingolfsson HI
PROVIDER: S-EPMC3188397 | biostudies-literature | 2011 Oct
REPOSITORIES: biostudies-literature
Publications
Effects of green tea catechins on gramicidin channel function and inferred changes in bilayer properties.
Ingólfsson Helgi I HI Koeppe Roger E RE Andersen Olaf S OS
FEBS letters 20110901 19
Green tea's health benefits have been attributed to its major polyphenols, the catechins: (-)-epigallocatechin gallate (EGCG), (-)-epicatechin gallate (ECG), (-)-epigallocatechin (EGC), and epicatechin (EC). Catechins (especially EGCG) modulate a wide range of biologically important molecules, including many membrane proteins. Yet, little is known about their mechanism(s) of action. We tested the catechins' bilayer-modifying potency using gramicidin A (gA) channels as molecular force probes. All ...[more]
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