Ontology highlight
ABSTRACT:
SUBMITTER: Verzijlbergen KF
PROVIDER: S-EPMC3188528 | biostudies-literature | 2011 Oct
REPOSITORIES: biostudies-literature
Verzijlbergen Kitty F KF van Welsem Tibor T Sie Daoud D Lenstra Tineke L TL Turner Daniel J DJ Holstege Frank C P FC Kerkhoven Ron M RM van Leeuwen Fred F
PLoS genetics 20111006 10
Dynamic modification of histone proteins plays a key role in regulating gene expression. However, histones themselves can also be dynamic, which potentially affects the stability of histone modifications. To determine the molecular mechanisms of histone turnover, we developed a parallel screening method for epigenetic regulators by analyzing chromatin states on DNA barcodes. Histone turnover was quantified by employing a genetic pulse-chase technique called RITE, which was combined with chromati ...[more]