MM-ChIP enables integrative analysis of cross-platform and between-laboratory ChIP-chip or ChIP-seq data.
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ABSTRACT:
SUBMITTER: Chen Y
PROVIDER: S-EPMC3188793 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
Publications
MM-ChIP enables integrative analysis of cross-platform and between-laboratory ChIP-chip or ChIP-seq data.
Chen Yiwen Y Meyer Clifford A CA Liu Tao T Li Wei W Liu Jun S JS Liu Xiaole Shirley XS
Genome biology 20110201 2
The ChIP-chip and ChIP-seq techniques enable genome-wide mapping of in vivo protein-DNA interactions and chromatin states. The cross-platform and between-laboratory variation poses a challenge to the comparison and integration of results from different ChIP experiments. We describe a novel method, MM-ChIP, which integrates information from cross-platform and between-laboratory ChIP-chip or ChIP-seq datasets. It improves both the sensitivity and the specificity of detecting ChIP-enriched regions, ...[more]
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