Ontology highlight
ABSTRACT:
SUBMITTER: Son EY
PROVIDER: S-EPMC3188987 | biostudies-literature | 2011 Sep
REPOSITORIES: biostudies-literature
Son Esther Y EY Ichida Justin K JK Wainger Brian J BJ Toma Jeremy S JS Rafuse Victor F VF Woolf Clifford J CJ Eggan Kevin K
Cell stem cell 20110901 3
The mammalian nervous system comprises many distinct neuronal subtypes, each with its own phenotype and differential sensitivity to degenerative disease. Although specific neuronal types can be isolated from rodent embryos or engineered from stem cells for translational studies, transcription factor-mediated reprogramming might provide a more direct route to their generation. Here we report that the forced expression of select transcription factors is sufficient to convert mouse and human fibrob ...[more]