Lateral sorting in model membranes by cholesterol-mediated hydrophobic matching.
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ABSTRACT:
SUBMITTER: Kaiser HJ
PROVIDER: S-EPMC3189033 | biostudies-literature | 2011 Oct
REPOSITORIES: biostudies-literature
Publications
Lateral sorting in model membranes by cholesterol-mediated hydrophobic matching.
Kaiser Hermann-Josef HJ Orłowski Adam A Róg Tomasz T Nyholm Thomas K M TK Chai Wengang W Feizi Ten T Lingwood Daniel D Vattulainen Ilpo I Simons Kai K
Proceedings of the National Academy of Sciences of the United States of America 20110919 40
Theoretical studies predict hydrophobic matching between transmembrane domains of proteins and bilayer lipids to be a physical mechanism by which membranes laterally self-organize. We now experimentally study the direct consequences of mismatching of transmembrane peptides of different length with bilayers of different thicknesses at the molecular level. In both model membranes and simulations we show that cholesterol critically constrains structural adaptations at the peptide-lipid interface un ...[more]
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