Ontology highlight
ABSTRACT:
SUBMITTER: Shu D
PROVIDER: S-EPMC3189281 | biostudies-literature | 2011 Sep
REPOSITORIES: biostudies-literature
Shu Dan D Shu Yi Y Haque Farzin F Abdelmawla Sherine S Guo Peixuan P
Nature nanotechnology 20110911 10
RNA nanoparticles have applications in the treatment of cancers and viral infection; however, the instability of RNA nanoparticles has hindered their development for therapeutic applications. The lack of covalent linkage or crosslinking in nanoparticles causes dissociation in vivo. Here we show that the packaging RNA of bacteriophage phi29 DNA packaging motor can be assembled from 3-6 pieces of RNA oligomers without the use of metal salts. Each RNA oligomer contains a functional module that can ...[more]