Ontology highlight
ABSTRACT:
SUBMITTER: Hong SK
PROVIDER: S-EPMC3189339 | biostudies-literature | 2011 Nov
REPOSITORIES: biostudies-literature
Experimental cell research 20110816 18
Upregulated ERK1/2 activity is correlated with androgen receptor (AR) downregulation in certain prostate cancer (PCa) that exhibits androgen deprivation-induced neuroendocrine differentiation, but its functional relevance requires elucidation. We found that sustained ERK1/2 activation using active Raf or MEK1/2 mutants is sufficient to induce AR downregulation at mRNA and protein levels in LNCaP. Downregulation of AR protein, but not mRNA, was blocked by proteasome inhibitors, MG132 and bortezom ...[more]