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Rhein induces apoptosis in human breast cancer cells.

ABSTRACT: Human breast cancers cells overexpressing HER2/neu are more aggressive tumors with poor prognosis, and resistance to chemotherapy. This study investigates antiproliferation effects of anthraquinone derivatives of rhubarb root on human breast cancer cells. Of 7 anthraquinone derivatives, only rhein showed antiproliferative and apoptotic effects on both HER2-overexpressing MCF-7 (MCF-7/HER2) and control vector MCF-7 (MCF-7/VEC) cells. Rhein induced dose- and time-dependent manners increase in caspase-9-mediated apoptosis correlating with activation of ROS-mediated activation of NF-?B- and p53-signaling pathways in both cell types. Therefore, this study highlighted rhein as processing anti-proliferative activity against HER2 overexpression or HER2-basal expression in breast cancer cells and playing important roles in apoptotic induction of human breast cancer cells.

SUBMITTER: Chang CY

PROVIDER: S-EPMC3189565 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature

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Rhein induces apoptosis in human breast cancer cells.

Chang Ching-Yao CY Chan Hong-Lin HL Lin Hui-Yi HY Way Tzong-Der TD Kao Ming-Ching MC Song Ming-Zhang MZ Lin Ying-Ju YJ Lin Cheng-Wen CW

Evidence-based complementary and alternative medicine : eCAM 20111005

Human breast cancers cells overexpressing HER2/neu are more aggressive tumors with poor prognosis, and resistance to chemotherapy. This study investigates antiproliferation effects of anthraquinone derivatives of rhubarb root on human breast cancer cells. Of 7 anthraquinone derivatives, only rhein showed antiproliferative and apoptotic effects on both HER2-overexpressing MCF-7 (MCF-7/HER2) and control vector MCF-7 (MCF-7/VEC) cells. Rhein induced dose- and time-dependent manners increase in casp ...[more]

PMID: 22007260

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