Ontology highlight
ABSTRACT:
SUBMITTER: Rodrigues AC
PROVIDER: S-EPMC3189752 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
Rodrigues Alice C AC Perin Paula M S PM Purim Sheila G SG Silbiger Vivian N VN Genvigir Fabiana D V FD Willrich Maria Alice V MA Arazi Simone S SS Luchessi Andre D AD Hirata Mario H MH Bernik Marcia M S MM Dorea Egidio L EL Santos Carla C Faludi Andre A AA Bertolami Marcelo C MC Salas Antonio A Freire Ana A Lareu Maria V MV Phillips Christopher C Porras-Hurtado Liliana L Fondevila Manuel M Carracedo Angel A Hirata Rosario D C RD
International journal of molecular sciences 20110909 9
<h4>Aims</h4>The relationship between variants in SLCO1B1 and SLCO2B1 genes and lipid-lowering response to atorvastatin was investigated.<h4>Material and methods</h4>One-hundred-thirty-six unrelated individuals with hypercholesterolemia were selected and treated with atorvastatin (10 mg/day/4 weeks). They were genotyped with a panel of ancestry informative markers for individual African component of ancestry (ACA) estimation by SNaPshot(®) and SLCO1B1 (c.388A>G, c.463C>A and c.521T>C) and SLCO2B ...[more]