Ontology highlight
ABSTRACT:
SUBMITTER: Smith SA
PROVIDER: S-EPMC3190034 | biostudies-literature | 2011 Oct
REPOSITORIES: biostudies-literature
Smith S A SA Williams Z R ZR Ratchford J N JN Newsome S D SD Farrell S K SK Farrell J A D JA Gifford A A Miller N R NR van Zijl P C M PC Calabresi P A PA Reich D S DS
AJNR. American journal of neuroradiology 20110728 9
<h4>Background and purpose</h4>There is a well-known relationship between MS and damage to the optic nerve, but advanced, quantitative MR imaging methods have not been applied to large cohorts. Our objective was to determine whether a short imaging protocol (< 10 minutes), implemented with standard hardware, could detect abnormal water diffusion in the optic nerves of patients with MS.<h4>Materials and methods</h4>We examined water diffusion in human optic nerves via DTI in the largest MS cohort ...[more]