Ontology highlight
ABSTRACT:
SUBMITTER: Anney RJ
PROVIDER: S-EPMC3190264 | biostudies-literature | 2011 Oct
REPOSITORIES: biostudies-literature
Anney Richard J L RJ Kenny Elaine M EM O'Dushlaine Colm C Yaspan Brian L BL Parkhomenka Elena E Buxbaum Joseph D JD Sutcliffe James J Gill Michael M Gallagher Louise L Buxbaum Joseph D JD Sutcliffe James J Gill Michael M Gallagher Louise L
European journal of human genetics : EJHG 20110427 10
Recent genome-wide association studies (GWAS) have implicated a range of genes from discrete biological pathways in the aetiology of autism. However, despite the strong influence of genetic factors, association studies have yet to identify statistically robust, replicated major effect genes or SNPs. We apply the principle of the SNP ratio test methodology described by O'Dushlaine et al to over 2100 families from the Autism Genome Project (AGP). Using a two-stage design we examine association enr ...[more]