The LptD chaperone LptE is not directly involved in lipopolysaccharide transport in Neisseria meningitidis.

ABSTRACT: The biosynthesis of lipopolysaccharide (LPS) in gram-negative bacteria is well understood, in contrast to the transport to its destination, the outer leaflet of the outer membrane. In Escherichia coli, synthesis and transport of LPS are essential processes. Neisseria meningitidis, conversely, can survive without LPS and tolerates inactivation of genes involved in LPS synthesis and transport. Here, we analyzed whether the LptA, LptB, LptC, LptE, LptF, and LptG proteins, recently implicated in LPS transport in E. coli, function similarly in N. meningitidis. None of the analyzed proteins was essential in N. meningitidis, consistent with their expected roles in LPS transport and additionally demonstrating that they are not required for an essential process such as phospholipid transport. As ex

SUBMITTER: Bos MP 

PROVIDER: S-EPMC3190676 | biostudies-literature | 2011 Aug

REPOSITORIES: biostudies-literature