Ontology highlight
ABSTRACT:
SUBMITTER: Singh SK
PROVIDER: S-EPMC3190684 | biostudies-literature | 2011 Aug
REPOSITORIES: biostudies-literature
Singh Shiv K SK Baumgart Sandra S Singh Garima G König Alexander O AO Reutlinger Kristina K Hofbauer Lorenz C LC Barth Peter P Gress Thomas M TM Lomberk Gwen G Urrutia Raul R Fernandez-Zapico Martin E ME Ellenrieder Volker V
The Journal of biological chemistry 20110531 33
The aminobisphosphonate zoledronic acid has elicited significant attention due to its remarkable anti-tumoral activity, although its detailed mechanism of action remains unclear. Here, we demonstrate the existence of a nuclear GSK-3β-NFATc2 stabilization pathway that promotes breast and pancreatic cancer growth in vitro and in vivo and serves as a bona fide target of zoledronic acid. Specifically, the serine/threonine kinase GSK-3β stabilizes nuclear NFATc2 through phosphorylation of the serine- ...[more]