Ontology highlight
ABSTRACT:
SUBMITTER: Wang S
PROVIDER: S-EPMC3190743 | biostudies-literature | 2011 Aug
REPOSITORIES: biostudies-literature
Wang Songyu S Thibault Guillaume G Ng Davis T W DTW
The Journal of biological chemistry 20110627 33
The secretory pathway maintains multiple quality control checkpoints. Initially, endoplasmic reticulum-associated degradation pathways monitor protein folding to retain and eliminate aberrant products. Despite its broad client range, some molecules escape detection and traffic to Golgi membranes. There, a poorly understood mechanism termed Golgi quality control routes aberrant proteins for lysosomal/vacuolar degradation. To better understand Golgi quality control, we examined the processing of t ...[more]