Ontology highlight
ABSTRACT:
SUBMITTER: Koutmos M
PROVIDER: S-EPMC3191019 | biostudies-literature | 2011 Aug
REPOSITORIES: biostudies-literature
Koutmos Markos M Gherasim Carmen C Smith Janet L JL Banerjee Ruma R
The Journal of biological chemistry 20110622 34
An early step in the intracellular processing of vitamin B(12) involves CblC, which exhibits dual reactivity, catalyzing the reductive decyanation of cyanocobalamin (vitamin B(12)), and the dealkylation of alkylcobalamins (e.g. methylcobalamin; MeCbl). Insights into how the CblC scaffold supports this chemical dichotomy have been unavailable despite it being the most common locus of patient mutations associated with inherited cobalamin disorders that manifest in both severe homocystinuria and me ...[more]