Ontology highlight
ABSTRACT:
SUBMITTER: Crosby LM
PROVIDER: S-EPMC3191757 | biostudies-literature | 2011 Oct
REPOSITORIES: biostudies-literature
Crosby Lynn M LM Luellen Charlean C Zhang Zhihong Z Tague Larry L LL Sinclair Scott E SE Waters Christopher M CM
American journal of physiology. Lung cellular and molecular physiology 20110701 4
After acute lung injury, repair of the alveolar epithelium occurs on a substrate undergoing cyclic mechanical deformation. While previous studies showed that mechanical stretch increased alveolar epithelial cell necrosis and apoptosis, the impact of cell death during repair was not determined. We examined epithelial repair during cyclic stretch (CS) in a scratch-wound model of primary rat alveolar type II (ATII) cells and found that CS altered the balance between proliferation and cell death. We ...[more]