Ontology highlight
ABSTRACT:
SUBMITTER: Chun J
PROVIDER: S-EPMC3192023 | biostudies-literature | 2009 Nov
REPOSITORIES: biostudies-literature
Journal of leukocyte biology 20090715 5
In airway cells, TLR2 stimulation by bacterial products activates Ca2+ fluxes that signal leukocyte recruitment to the lung and facilitates transepithelial migration into the airway lumen. TLR2 is apically displayed on airway cells, where it senses bacterial stimuli. Biochemical and genetic approaches demonstrate that TLR2 ligands stimulate release of Ca2+ from intracellular stores by activating TLR2 phosphorylation by c-Src and recruiting PI3K and PLCgamma to affect Ca2+ release through IP3Rs. ...[more]