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Immune activation in the female genital tract during HIV infection predicts mucosal CD4 depletion and HIV shedding.


ABSTRACT: Plasma viral load predicts genital tract human immunodeficiency virus (HIV) shedding in HIV-infected women. We investigated whether local mucosal T-cell activation (HLA-DR, CD38, CCR5, and Ki67) contributed to HIV shedding in the genital tracts of HIV-infected women. We showed that cervical cytobrush-derived T cells expressed higher frequencies of T-cell activation markers (CD38+ and HLA-DR+) than blood-derived T cells. Expression was significantly higher in HIV-infected women than in uninfected women. We found that the frequency of activated proliferating cervical T cells (Ki67+; Ki67+CCR5+) broadly predicted HIV shedding in the genital tract in HIV-infected women, independently of plasma viral loads. Furthermore, activated cervical T cells (HLA-DR+CD38+ and HLA-DR+CCR5+) and local HIV shedding were independently associated with CD4 depletion in the genital tract. These data suggest that the presence of high frequencies of activated T cells in the female genital mucosa during HIV infection facilitates both local HIV shedding and CD4 T-cell depletion.

SUBMITTER: Jaspan HB 

PROVIDER: S-EPMC3192190 | biostudies-literature | 2011 Nov

REPOSITORIES: biostudies-literature

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Immune activation in the female genital tract during HIV infection predicts mucosal CD4 depletion and HIV shedding.

Jaspan Heather B HB   Liebenberg Lenine L   Hanekom Willem W   Burgers Wendy W   Coetzee David D   Williamson Anna-Lise AL   Little Francesca F   Myer Landon L   Coombs Robert W RW   Sodora Don D   Passmore Jo-Ann JA  

The Journal of infectious diseases 20110921 10


Plasma viral load predicts genital tract human immunodeficiency virus (HIV) shedding in HIV-infected women. We investigated whether local mucosal T-cell activation (HLA-DR, CD38, CCR5, and Ki67) contributed to HIV shedding in the genital tracts of HIV-infected women. We showed that cervical cytobrush-derived T cells expressed higher frequencies of T-cell activation markers (CD38+ and HLA-DR+) than blood-derived T cells. Expression was significantly higher in HIV-infected women than in uninfected  ...[more]

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