Ontology highlight
ABSTRACT:
SUBMITTER: Sammond DW
PROVIDER: S-EPMC3192311 | biostudies-literature | 2011 Nov
REPOSITORIES: biostudies-literature
Sammond Deanne W DW Joce Catherine C Takeshita Ryan R McQuate Sarah E SE Ghosh Nilanjan N Martin Jennifer M JM Yin Hang H
Biopolymers 20110510 11
Epstein-Barr virus (EBV), a human γ-herpesvirus, establishes lifelong infection by targeting the adaptive immune system of the host through memory B cells. Although normally benign, EBV contributes to lymphoid malignancies and lymphoproliferative syndromes in immunocompromised individuals. The viral oncoprotein latent membrane protein 1 (LMP-1) is essential for B lymphocyte immortalization by EBV. The constitutive signaling activity of LMP-1 is dependent on homo-oligomerization of its six-spanni ...[more]