Ontology highlight
ABSTRACT:
SUBMITTER: Seo IR
PROVIDER: S-EPMC3192407 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
Seo In Ra IR Kang Dae Eun DE Song Dong Woo DW Kim Do Han DH
Journal of biomedicine & biotechnology 20111005
Imperatoxin A (IpTx(a)) is known to modify the gating of skeletal ryanodine receptor (RyR1). In this paper, the ability of charged aa residues of IpTx(a) to induce substate of native RyR1 in HSR was examined. Our results show that the basic residues (e.g., Lys¹⁹, Lys²⁰, Lys²², Arg²³, and Arg²⁴) are important for producing substate of RyR1. In addition, other basic residues (e.g., Lys³⁰, Arg³¹, and Arg³³ near the C-terminus and some acidic residues (e.g., Glu²⁹, Asp¹³, and Asp²) are also involved ...[more]