Ontology highlight
ABSTRACT:
SUBMITTER: Aitken S
PROVIDER: S-EPMC3192812 | biostudies-literature | 2011 Oct
REPOSITORIES: biostudies-literature
Aitken Stuart S Alexander Ross D RD Beggs Jean D JD
PLoS computational biology 20111013 10
Messenger RNA splicing is an essential and complex process for the removal of intron sequences. Whereas the composition of the splicing machinery is mostly known, the kinetics of splicing, the catalytic activity of splicing factors and the interdependency of transcription, splicing and mRNA 3' end formation are less well understood. We propose a stochastic model of splicing kinetics that explains data obtained from high-resolution kinetic analyses of transcription, splicing and 3' end formation ...[more]