Ontology highlight
ABSTRACT:
SUBMITTER: Brackley CA
PROVIDER: S-EPMC3192816 | biostudies-literature | 2011 Oct
REPOSITORIES: biostudies-literature
PLoS computational biology 20111013 10
We study the elongation stage of mRNA translation in eukaryotes and find that, in contrast to the assumptions of previous models, both the supply and the demand for tRNA resources are important for determining elongation rates. We find that increasing the initiation rate of translation can lead to the depletion of some species of aa-tRNA, which in turn can lead to slow codons and queueing. Particularly striking "competition" effects are observed in simulations of multiple species of mRNA which a ...[more]