Ontology highlight
ABSTRACT:
SUBMITTER: Zhang Y
PROVIDER: S-EPMC3192910 | biostudies-literature | 2011 Nov
REPOSITORIES: biostudies-literature
Zhang Yongfang Y Kurup Pradeep P Xu Jian J Anderson George M GM Greengard Paul P Nairn Angus C AC Lombroso Paul J PJ
Journal of neurochemistry 20110921 3
Striatal-Enriched protein tyrosine Phosphatase of MW 61 kDa (STEP(61)) is a protein tyrosine phosphatase recently implicated in the pathophysiology of Alzheimer's disease (AD). STEP(61) is elevated in human AD prefrontal cortex and in the cortex of several AD mouse models. The elevated levels of active STEP(61) down-regulate surface expression of GluN1/GluN2B (formerly NR1/NR2B) receptor complexes, while genetically reducing STEP levels rescues both the biochemical and cognitive deficits in a tr ...[more]