Ontology highlight
ABSTRACT:
SUBMITTER: Benod C
PROVIDER: S-EPMC3193228 | biostudies-literature | 2011 Oct
REPOSITORIES: biostudies-literature
Benod Cindy C Vinogradova Maia V MV Jouravel Natalia N Kim Grace E GE Fletterick Robert J RJ Sablin Elena P EP
Proceedings of the National Academy of Sciences of the United States of America 20110926 41
An essential regulator of gene transcription, nuclear receptor liver receptor homologue 1 (LRH-1) controls cell differentiation in the developing pancreas and maintains cholesterol homeostasis in adults. Recent genome-wide association studies linked mutations in the LRH-1 gene and its up-stream regulatory regions to development of pancreatic cancer. In this work, we show that LRH-1 transcription is activated up to 30-fold in human pancreatic cancer cells compared to normal pancreatic ductal epit ...[more]