Ontology highlight
ABSTRACT:
SUBMITTER: Wang GY
PROVIDER: S-EPMC3193585 | biostudies-literature | 2011 Nov
REPOSITORIES: biostudies-literature
Wang Grace Ying GY So Po-Lin PL Wang Lynn L Libove Eileen E Wang Joy J Epstein Ervin H EH
The Journal of investigative dermatology 20110811 11
Dysregulated hedgehog (HH) signaling has been found in numerous cancers, suggesting that therapeutic targeting of this pathway may be useful versus a wide range of cancers. Basal cell carcinoma (BCC) is an excellent model system for studying the influence of the HH pathway on carcinogenesis because aberrant activation of HH signaling is crucial not only for the development of but also the maintenance of BCC. Genetically engineered BCC mouse models provide one important tool for the study of the ...[more]