Historical and current perspective on tobacco use and nicotine addiction.
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ABSTRACT:
SUBMITTER: Dani JA
PROVIDER: S-EPMC3193858 | biostudies-literature | 2011 Jul
REPOSITORIES: biostudies-literature
Publications
Historical and current perspective on tobacco use and nicotine addiction.
Dani John A JA Balfour David J K DJ
Trends in neurosciences 20110621 7
Although the addictive influence of tobacco was recognized very early, the modern concepts of nicotine addiction have relied on knowledge of cholinergic neurotransmission and nicotinic acetylcholine receptors (nAChRs). The discovery of the 'receptive substance' by Langley, that would turn out to be nAChRs, and 'Vagusstoff' (acetylcholine) by Loewi, coincided with an exciting time when the concept of chemical synaptic transmission was being formulated. More recently, the application of more power ...[more]
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