Ontology highlight
ABSTRACT:
SUBMITTER: Moran-Crusio K
PROVIDER: S-EPMC3194039 | biostudies-literature | 2011 Jul
REPOSITORIES: biostudies-literature
Moran-Crusio Kelly K Reavie Linsey L Shih Alan A Abdel-Wahab Omar O Ndiaye-Lobry Delphine D Lobry Camille C Figueroa Maria E ME Vasanthakumar Aparna A Patel Jay J Zhao Xinyang X Perna Fabiana F Pandey Suveg S Madzo Jozef J Song Chunxiao C Dai Qing Q He Chuan C Ibrahim Sherif S Beran Miloslav M Zavadil Jiri J Nimer Stephen D SD Melnick Ari A Godley Lucy A LA Aifantis Iannis I Levine Ross L RL
Cancer cell 20110630 1
Somatic loss-of-function mutations in the ten-eleven translocation 2 (TET2) gene occur in a significant proportion of patients with myeloid malignancies. Although there are extensive genetic data implicating TET2 mutations in myeloid transformation, the consequences of Tet2 loss in hematopoietic development have not been delineated. We report here an animal model of conditional Tet2 loss in the hematopoietic compartment that leads to increased stem cell self-renewal in vivo as assessed by compet ...[more]