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Attract: A method for identifying core pathways that define cellular phenotypes.


ABSTRACT: attract is a knowledge-driven analytical approach for identifying and annotating the gene-sets that best discriminate between cell phenotypes. attract finds distinguishing patterns within pathways, decomposes pathways into meta-genes representative of these patterns, and then generates synexpression groups of highly correlated genes from the entire transcriptome dataset. attract can be applied to a wide range of biological systems and is freely available as a Bioconductor package and has been incorporated into the MeV software system.

SUBMITTER: Mar JC 

PROVIDER: S-EPMC3194807 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature

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attract: A method for identifying core pathways that define cellular phenotypes.

Mar Jessica C JC   Matigian Nicholas A NA   Quackenbush John J   Wells Christine A CA  

PloS one 20111014 10


attract is a knowledge-driven analytical approach for identifying and annotating the gene-sets that best discriminate between cell phenotypes. attract finds distinguishing patterns within pathways, decomposes pathways into meta-genes representative of these patterns, and then generates synexpression groups of highly correlated genes from the entire transcriptome dataset. attract can be applied to a wide range of biological systems and is freely available as a Bioconductor package and has been in  ...[more]

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