Fractal geometry and the pharmacometrics of micafungin in overweight, obese, and extremely obese people.

ABSTRACT: The majority of Americans are overweight, and the incidence of obesity continues to increase. This trend predisposes people to a number of deleterious consequences, including the metabolic syndrome and other conditions that lead to a greater number of hospital admissions. Invasive candidiasis is an important nosocomial infection that results from these admissions. Echinocandins such as micafungin are indicated for treatment. We have previously demonstrated that overweight patients exhibit higher micafungin systemic clearance (SCL) than leaner patients. We hypothesized that obese and extremely obese people would show even higher SCL than merely overweight patients. To test this, we performed a prospective study of 36 adult volunteers randomized to receive a single dose of either 100 mg or 3

SUBMITTER: Hall RG 

PROVIDER: S-EPMC3195005 | biostudies-literature | 2011 Nov

REPOSITORIES: biostudies-literature