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Selective killing of bacterial persisters by a single chemical compound without affecting normal antibiotic-sensitive cells.

ABSTRACT: We show that 3-[4-(4-methoxyphenyl)piperazin-1-yl]piperidin-4-yl biphenyl-4-carboxylate (C10), screened out of a chemical library, selectively kills bacterial persisters that tolerate antibiotic treatment but does not affect normal antibiotic-sensitive cells. C10 led persisters to antibiotic-induced cell death by causing reversion of persisters to antibiotic-sensitive cells. This work is the first demonstration in which the eradication of bacterial persisters is based on single-chemical supplementation. The chemical should be versatile in elucidating the mechanism of persistence.

SUBMITTER: Kim JS

PROVIDER: S-EPMC3195057 | biostudies-literature | 2011 Nov

REPOSITORIES: biostudies-literature

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Selective killing of bacterial persisters by a single chemical compound without affecting normal antibiotic-sensitive cells.

Kim Jun-Seob JS Heo Paul P Yang Tae-Jun TJ Lee Ki-Sing KS Cho Da-Hyeong DH Kim Bum Tae BT Suh Ji-Hee JH Lim Hee-Jong HJ Shin Dongwoo D Kim Sung-Koo SK Kweon Dae-Hyuk DH

Antimicrobial agents and chemotherapy 20110815 11

We show that 3-[4-(4-methoxyphenyl)piperazin-1-yl]piperidin-4-yl biphenyl-4-carboxylate (C10), screened out of a chemical library, selectively kills bacterial persisters that tolerate antibiotic treatment but does not affect normal antibiotic-sensitive cells. C10 led persisters to antibiotic-induced cell death by causing reversion of persisters to antibiotic-sensitive cells. This work is the first demonstration in which the eradication of bacterial persisters is based on single-chemical suppleme ...[more]

PMID: 21844322

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