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Tryptophan research in panic disorder.


ABSTRACT: A considerable body of evidence suggests the involvement of serotonin neurotransmission in the pathogenesis of panic disorder. Research on pathways and functions of tryptophan, an essential amino acid converted into serotonin, may advance our understanding of serotonergic actions in panic disorder and related phenomena. The investigative approaches in this field include manipulations of tryptophan availability as well as genetic association and functional brain imaging studies. In this review we examine the principle findings of these studies and propose further research directions.

SUBMITTER: Maron E 

PROVIDER: S-EPMC3195213 | biostudies-literature | 2008

REPOSITORIES: biostudies-literature

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Tryptophan research in panic disorder.

Maron Eduard E   Shlik Jakov J   Nutt David J DJ  

International journal of tryptophan research : IJTR 20080814


A considerable body of evidence suggests the involvement of serotonin neurotransmission in the pathogenesis of panic disorder. Research on pathways and functions of tryptophan, an essential amino acid converted into serotonin, may advance our understanding of serotonergic actions in panic disorder and related phenomena. The investigative approaches in this field include manipulations of tryptophan availability as well as genetic association and functional brain imaging studies. In this review we  ...[more]

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