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IDO-Mediated Tryptophan Degradation in the Pathogenesis of Malignant Tumor Disease.


ABSTRACT: Immune escape is a fundamental trait of cancer in which the Th1-type cytokine interferon- ? (IFN-?) seems to play a key role. Among other tumoricidal biochemical pathways, IFN-? induces the tryptophan-degrading enzyme indoleamine 2,3-dioxygenase (IDO) in a variety of cells including macrophages, dendritic cells (DCs) and tumor cells. IDO activity has been shown to reflect the extent and the course in a plethora of malignancies including prostate, colorectal, pancreatic, cervical, endometrial, gastric, lung, bladder, ovarian, esophageal and renal cell carcinomas, glioblastomas, mesotheliomas, and melanomas. Furthermore IDO activity during malignant tumor diseases seems to be part of the tumoricidal immune defense strategy, which in the long run is detrimental to the host, when tryptophan deprivation and production of pro-apoptotic tryptophan catabolites counteract T-cell responsiveness.

SUBMITTER: Sucher R 

PROVIDER: S-EPMC3195236 | biostudies-literature | 2010

REPOSITORIES: biostudies-literature

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IDO-Mediated Tryptophan Degradation in the Pathogenesis of Malignant Tumor Disease.

Sucher Robert R   Kurz Katharina K   Weiss Guenter G   Margreiter Raimund R   Fuchs Dietmar D   Brandacher Gerald G  

International journal of tryptophan research : IJTR 20100610


Immune escape is a fundamental trait of cancer in which the Th1-type cytokine interferon- γ (IFN-γ) seems to play a key role. Among other tumoricidal biochemical pathways, IFN-γ induces the tryptophan-degrading enzyme indoleamine 2,3-dioxygenase (IDO) in a variety of cells including macrophages, dendritic cells (DCs) and tumor cells. IDO activity has been shown to reflect the extent and the course in a plethora of malignancies including prostate, colorectal, pancreatic, cervical, endometrial, ga  ...[more]

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