Ontology highlight
ABSTRACT:
SUBMITTER: Sucher R
PROVIDER: S-EPMC3195236 | biostudies-literature | 2010
REPOSITORIES: biostudies-literature
Sucher Robert R Kurz Katharina K Weiss Guenter G Margreiter Raimund R Fuchs Dietmar D Brandacher Gerald G
International journal of tryptophan research : IJTR 20100610
Immune escape is a fundamental trait of cancer in which the Th1-type cytokine interferon- γ (IFN-γ) seems to play a key role. Among other tumoricidal biochemical pathways, IFN-γ induces the tryptophan-degrading enzyme indoleamine 2,3-dioxygenase (IDO) in a variety of cells including macrophages, dendritic cells (DCs) and tumor cells. IDO activity has been shown to reflect the extent and the course in a plethora of malignancies including prostate, colorectal, pancreatic, cervical, endometrial, ga ...[more]