Ontology highlight
ABSTRACT:
SUBMITTER: Hong E
PROVIDER: S-EPMC3195411 | biostudies-literature | 2009 Jul
REPOSITORIES: biostudies-literature
Hong Eunmi E Doucleff Michaeleen M Wemmer David E DE
Journal of molecular biology 20090505 1
Transcription initiation by bacterial sigma(54)-RNA polymerase requires a conformational change of the holopolymerase-DNA complex, driven by an enhancer-binding protein. Although structures of the core polymerase and the more common sigma(70) factor have been determined, little is known about the structure of the sigma(54) variant. We report here the structure of an Aquifex aeolicus sigma(54) domain (residues 69-198), which binds core RNA polymerase. The structure is composed of two distinct sub ...[more]