Ontology highlight
ABSTRACT:
SUBMITTER: Egan CE
PROVIDER: S-EPMC3196813 | biostudies-literature | 2011 Nov
REPOSITORIES: biostudies-literature
Egan C E CE Maurer K J KJ Cohen S B SB Mack M M Simpson K W KW Denkers E Y EY
Mucosal immunology 20110727 6
Oral infection of C57BL/6 mice with Toxoplasma gondii triggers severe necrosis in the ileum within 7-10 days of infection. Lesion development is mediated by Th-1 cytokines, CD4+ T cells, and subepithelial bacterial translocation. As such, these features share similarity to Crohn's disease. Recently, we uncovered a role for intraepithelial lymphocytes (IELs) in mediating pathology after Toxoplasma infection. We show here that αβ and not γδ T-cell IELs mediate intestinal damage. By adoptive transf ...[more]