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N-CAM exhibits a regulatory function in pathological angiogenesis in oxygen induced retinopathy.


ABSTRACT:

Background

Diabetic retinopathy and retinopathy of prematurity are diseases caused by pathological angiogenesis in the retina as a consequence of local hypoxia. The underlying mechanism for epiretinal neovascularization (tuft formation), which contributes to blindness, has yet to be identified. Neural cell adhesion molecule (N-CAM) is expressed by Müller cells and astrocytes, which are in close contact with the retinal vasculature, during normal developmental angiogenesis.

Methodology/principal findings

Notably, during oxygen induced retinopathy (OIR) N-CAM accumulated on astrocytes surrounding the epiretinal tufts. Here, we show that N-CAM ablation results in reduced vascular tuft formation due to reduced endothelial cell proliferation despite an elevation in VEGFA mRNA expression, whereas retinal developmental angiogenesis was unaffected.

Conclusion/significance

We conclude that N-CAM exhibits a regulatory function in pathological angiogenesis in OIR. This is a novel finding that can be of clinical relevance in diseases associated with proliferative vasculopathy.

SUBMITTER: Hakansson J 

PROVIDER: S-EPMC3197149 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature

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N-CAM exhibits a regulatory function in pathological angiogenesis in oxygen induced retinopathy.

Håkansson Joakim J   Ståhlberg Anders A   Wolfhagen Sand Fredrik F   Gerhardt Holger H   Gerhardt Holger H   Semb Henrik H  

PloS one 20111017 10


<h4>Background</h4>Diabetic retinopathy and retinopathy of prematurity are diseases caused by pathological angiogenesis in the retina as a consequence of local hypoxia. The underlying mechanism for epiretinal neovascularization (tuft formation), which contributes to blindness, has yet to be identified. Neural cell adhesion molecule (N-CAM) is expressed by Müller cells and astrocytes, which are in close contact with the retinal vasculature, during normal developmental angiogenesis.<h4>Methodology  ...[more]

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