Ontology highlight
ABSTRACT:
SUBMITTER: Birkved FK
PROVIDER: S-EPMC3197845 | biostudies-literature | 2011 Nov
REPOSITORIES: biostudies-literature
Birkved Franziska Kramer FK Mortensen Alicja A Peñalvo José L JL Lindecrona Rikke H RH Sørensen Ilona Kryspin IK
Genes & nutrition 20110316 4
The aim of the present study was to investigate whether low flaxseed doses relevant to human dietary exposure can prevent mammary tumors in transgenic Tg.NK mice, a model of breast cancer. Animals were exposed to flaxseed through the diet at human relevant levels. Tumor-related parameters and tumor development were evaluated. Hepatic cytochrome P450 and glutathione S-transferase activities were significantly reduced in animals receiving low flaxseed doses. An incidence of palpable tumors before ...[more]