Ontology highlight
ABSTRACT:
SUBMITTER: Park ES
PROVIDER: S-EPMC3198333 | biostudies-literature | 2011 Oct
REPOSITORIES: biostudies-literature
Park Eun Sung ES Kim Sun Jin SJ Kim Seung Wook SW Yoon Se-Lyun SL Leem Sun-Hee SH Kim Sang-Bae SB Kim Soo Mi SM Park Yun-Yong YY Cheong Jae-Ho JH Woo Hyun Goo HG Mills Gordon B GB Fidler Isaiah J IJ Lee Ju-Seog JS
Proceedings of the National Academy of Sciences of the United States of America 20111010 42
Although the importance of the cellular microenvironment (soil) during invasion and metastasis of cancer cells (seed) has been well-recognized, technical challenges have limited the ability to assess the influence of the microenvironment on cancer cells at the molecular level. Here, we show that an experimental strategy, competitive cross-species hybridization of microarray experiments, can characterize the influence of different microenvironments on cancer cells by independently extracting gene ...[more]