Ontology highlight
ABSTRACT:
SUBMITTER: Inoue N
PROVIDER: S-EPMC3198342 | biostudies-literature | 2011 Oct
REPOSITORIES: biostudies-literature
Inoue Naoko N Sasagawa Karin K Ikai Kotaro K Sasaki Yuki Y Tomikawa Junko J Oishi Shinya S Fujii Nobutaka N Uenoyama Yoshihisa Y Ohmori Yasushige Y Yamamoto Naoyuki N Hondo Eiichi E Maeda Kei-ichiro K Tsukamura Hiroko H
Proceedings of the National Academy of Sciences of the United States of America 20111010 42
The present study investigated whether kisspeptin-G protein-coupled receptor 54 (GPR54) signaling plays a role in mediating mating-induced ovulation in the musk shrew (Suncus murinus), a reflex ovulator. For this purpose, we cloned suncus Kiss1 and Gpr54 cDNA from the hypothalamus and found that suncus kisspeptin (sKp) consists of 29 amino acid residues (sKp-29). Injection of exogenous sKp-29 mimicked the mating stimulus to induce follicular maturation and ovulation. Administration of several ki ...[more]