Cell-specific, activatable, and theranostic prodrug for dual-targeted cancer imaging and therapy.
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ABSTRACT:
SUBMITTER: Santra S
PROVIDER: S-EPMC3198802 | biostudies-literature | 2011 Oct
REPOSITORIES: biostudies-literature
Publications
Cell-specific, activatable, and theranostic prodrug for dual-targeted cancer imaging and therapy.
Santra Santimukul S Kaittanis Charalambos C Santiesteban Oscar J OJ Perez J Manuel JM
Journal of the American Chemical Society 20110927 41
Herein we describe the design and synthesis of a folate-doxorubicin conjugate with activatable fluorescence and activatable cytotoxicity. In this study we discovered that the cytotoxicity and fluorescence of doxorubicin are quenched (OFF) when covalently linked with folic acid. Most importantly, when the conjugate is designed with a disulfide bond linking the targeting folate unit and the cytotoxic doxorubicin, a targeted activatable prodrug is obtained that becomes activated (ON) within the cel ...[more]
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