Association between type-three metabotropic glutamate receptor gene (GRM3) variants and symptom presentation in treatment refractory schizophrenia.

ABSTRACT:

Objective

Positive associations between polymorphisms in the type-three metabotropic glutamate receptor gene (GRM3) and the pathogenesis of schizophrenia as well as response to antipsychotic treatment have been reported. The objective of this study was to determine whether refractory psychiatric symptoms in antipsychotic non-responders are related to polymorphisms in GRM3.

Methods

Ninety-five treatment refractory schizophrenia participants were enrolled. Prior to a medication switch, global psychopathology and negative symptoms were rated. These participants were genotyped for seven markers in GRM3. Genotype associations with symptoms were assessed.

Results

Two markers in GRM3 (rs1989796 and rs1476455), were associated with the presence of refractory global symptoms a

SUBMITTER: Bishop JR 

PROVIDER: S-EPMC3199025 | biostudies-literature | 2011 Jan

REPOSITORIES: biostudies-literature