Ontology highlight
ABSTRACT:
SUBMITTER: Schulte D
PROVIDER: S-EPMC3199392 | biostudies-literature | 2011 Aug
REPOSITORIES: biostudies-literature
Schulte Dörte D Küppers Verena V Dartsch Nina N Broermann Andre A Li Hang H Zarbock Alexander A Kamenyeva Olena O Kiefer Friedemann F Khandoga Alexander A Massberg Steffen S Vestweber Dietmar D
The EMBO journal 20110819 20
To determine whether leukocytes need to open endothelial cell contacts during extravasation, we decided to generate mice with strongly stabilized endothelial junctions. To this end, we replaced VE-cadherin genetically by a VE-cadherin-α-catenin fusion construct. Such mice were completely resistant to the induction of vascular leaks by VEGF or histamine. Neutrophil or lymphocyte recruitment into inflamed cremaster, lung and skin were strongly inhibited in these mice, documenting the importance of ...[more]