MicroRNA-34c is a novel target to treat dementias.
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ABSTRACT:
SUBMITTER: Zovoilis A
PROVIDER: S-EPMC3199394 | biostudies-literature | 2011 Sep
REPOSITORIES: biostudies-literature
Publications
microRNA-34c is a novel target to treat dementias.
Zovoilis Athanasios A Agbemenyah Hope Y HY Agis-Balboa Roberto C RC Stilling Roman M RM Edbauer Dieter D Rao Pooja P Farinelli Laurent L Delalle Ivana I Schmitt Andrea A Falkai Peter P Bahari-Javan Sanaz S Burkhardt Susanne S Sananbenesi Farahnaz F Fischer Andre A
The EMBO journal 20110923 20
MicroRNAs are key regulators of transcriptome plasticity and have been implicated with the pathogenesis of brain diseases. Here, we employed massive parallel sequencing and provide, at an unprecedented depth, the complete and quantitative miRNAome of the mouse hippocampus, the prime target of neurodegenerative diseases such as Alzheimer's disease (AD). Using integrative genetics, we identify miR-34c as a negative constraint of memory consolidation and show that miR-34c levels are elevated in the ...[more]
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