Ontology highlight
ABSTRACT:
SUBMITTER: Rietdorf K
PROVIDER: S-EPMC3199452 | biostudies-literature | 2011 Oct
REPOSITORIES: biostudies-literature
Rietdorf Katja K Funnell Tim M TM Ruas Margarida M Heinemann Jennifer J Parrington John J Galione Antony A
The Journal of biological chemistry 20110908 43
Two-pore channels (TPCs) have been recently identified as NAADP-regulated Ca(2+) release channels, which are localized on the endolysosomal system. TPCs have a 12-transmembrane domain (TMD) structure and are evolutionary intermediates between the 24-TMD α-subunits of Na(+) or Ca(2+) channels and the transient receptor potential channel superfamily, which have six TMDs in a single subunit and form tetramers with 24 TMDs as active channels. Based on this relationship, it is predicted that TPCs dim ...[more]