Comparative gene expression profiling of placentas from patients with severe pre-eclampsia and unexplained fetal growth restriction.

ABSTRACT:

Background

It has been well documented that pre-eclampsia and unexplained fetal growth restriction (FGR) have a common etiological background, but little is known about their linkage at the molecular level. The aim of this study was to further investigate the mechanisms underlying pre-eclampsia and unexplained FGR.

Methods

We analyzed differentially expressed genes in placental tissue from severe pre-eclamptic pregnancies (n = 8) and normotensive pregnancies with or (n = 8) without FGR (n = 8) using a microarray method.

Results

A subset of the FGR samples showed a high correlation coefficient overall in the microarray data from the pre-eclampsia samples. Many genes that are known to be up-regulated in pre-eclampsia are also up-regulated in FGR, including the anti-angi

SUBMITTER: Nishizawa H 

PROVIDER: S-EPMC3199758 | biostudies-literature | 2011 Aug

REPOSITORIES: biostudies-literature